BDBM50329315 (R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-carboxylic acid 5-carbamoyl-adamantan-2-yl ester::CHEMBL1269895

SMILES N#Cc1cccnc1N[C@@H]1CCN(C(=O)O[C@H]2C3CC4CC2C[C@](C(N)=O)(C4)C3)C1

InChI Key InChIKey=BNIGHFUMARRMFX-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50329315   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of 11betaHSD1 in human platelet assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 0.870nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate readerMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of recombinant 11betaHSD1 expressed in CHO cells assessed as [3H]-cortisone to [3H]-cortisol by microscintillation plate reader in presenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase type 2(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 7.35E+3nMAssay Description:Inhibition of 11betaHSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 3betaHSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of 17betaHSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Vitae Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50329315BDBM50329315((R)-3-(3-Cyano-pyridin-2-ylamino)-pyrrolidine-1-ca...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2011
Entry Details Article
PubMed