BDBM50331855 CHEMBL1289102::N'-(1-(3,4-dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide

SMILES COc1ccc(cc1)-c1cc([nH]n1)C(=O)NN=C(C)c1ccc(OC)c(OC)c1

InChI Key InChIKey=GMFUWEBOUKIKRP-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50331855   

TargetSphingosine kinase 1(Human)
Pennsylvania State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50331855(N'-(1-(3,4-dimethoxyphenyl)ethylidene)-3-(4-methox...)
Affinity DataKi:  1.33E+3nMAssay Description:Competitive inhibition of recombinant sphingosine kinase 1 using D-erythro-sphingosine as substrate by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetSphingosine kinase 1(Human)
Pennsylvania State University College of Medicine

Curated by ChEMBL
LigandPNGBDBM50331855(N'-(1-(3,4-dimethoxyphenyl)ethylidene)-3-(4-methox...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant His6x-tagged human SphK1 expressed in HEK293 cells assessed as reduction in S1P formation using D-erythro-sphingosine as su...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2022
Entry Details Article
PubMed