BDBM50340831 2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclobutyl)-4-methyl-4H-1,2,4-triazol-3-yl)phenyl)pyrazine::CHEMBL1760809

SMILES Cn1c(nnc1C1(CC(F)C1)c1ccc(Cl)cc1)-c1ccc(cc1Cl)-c1cnccn1

InChI Key InChIKey=QYSSEJDAEHAKCS-UHFFFAOYSA-N

Data  7 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50340831   

LigandPNGBDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO-K1 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of human 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of mouse 11beta-HSD2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
LigandPNGBDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at PXRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Merck

Curated by ChEMBL
LigandPNGBDBM50340831(2-(3-chloro-4-(5-(1-(4-chlorophenyl)-3-fluorocyclo...)
Affinity DataIC50: 3.60E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2011
Entry Details Article
PubMed