BDBM50367676 CHEMBL4160662
SMILES Cn1cc(-c2ccc(N(C(=O)NCc3ccccc3)[C@H]3CC[C@H](Nc4ccc(C#N)cn4)CC3)cc2)ccc1=O
InChI Key InChIKey=HDJBGURZVALLMD-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50367676
Affinity DataKd: 8.60nMAssay Description:Binding affinity to human CDK13 (694 to 1039 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interfe...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK13 (1 to 1512 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
Affinity DataKd: 16nMAssay Description:Binding affinity to human CDK12 (715 to 1052 residues)/CyclinK (1 to 267 residues) expressed in baculovirus infected in Sf9 cells by Biolayer interfe...More data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of CDK13/cyclin K (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 29nMAssay Description:Inhibition of CDK12/cyclin K (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 52nMAssay Description:Inhibition of N-terminal FLAG-tagged human full-length CDK12 (1 to 1490 residues)/N-terminal His-tagged CycK (1 to 580 residues) expressed in Sf9 cel...More data for this Ligand-Target Pair
Affinity DataIC50: 195nMAssay Description:Inhibition of CDK12 in human SK-BR-3 cells assessed as reduction in RNA polymerase 2 Ser2 phosphorylation incubated for 4 hrs byMore data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 515nMAssay Description:Inhibition of CDK9/Cyclin T1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 679nMAssay Description:Inhibition of CDK7/cyclin H/MAT1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 716nMAssay Description:Inhibition of CDK9/Cyclin K (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.21E+3nMAssay Description:Inhibition of CDK14/Cyclin Y (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of CDK15/Cyclin Y (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 4.79E+3nMAssay Description:Inhibition of CDK2/Cyclin A2 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of CDK5/p25NCK (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 5.07E+3nMAssay Description:Inhibition of CDK5/p35NCK (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 5.28E+3nMAssay Description:Inhibition of CDK4/Cyclin D1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.61E+3nMAssay Description:Inhibition of CDK3/cyclin E1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of CDK18/cyclin Y (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 8.01E+3nMAssay Description:Inhibition of CDK2/Cyclin E1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.79E+3nMAssay Description:Inhibition of CDK6/cyclin D1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/Cyclin E1 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 3/Cyclin-C(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK3/Cyclin C (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human GST-tagged CDK7/CycH/MAT1 (04 to 108 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human CDK8/CycC (04 to 109 residues) using kinase tracer 236 probe incubated for 60 mins by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 1(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1/Cyclin A2 (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK8/Cyclin C (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-Y/Cyclin-dependent kinase 16(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK16/cyclin Y (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-C/Cyclin-dependent kinase 19(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK19/Cyclin C (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of GST-tagged human CDK9/CycT1 (04 to 110 residues) assessed as reduction in ATP-dependent ULight-4E-BP1 (Thr37/Thr46) substrate peptide p...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Shanghai Institute of Organic Chemistry
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of GST-tagged human CDK2/CCNA2 (04 to 103 residues) pre-incubated for 5 mins before addition of histone H1 substrate and [gamma-33P]ATP an...More data for this Ligand-Target Pair