BDBM50390707 CHEMBL2070316::US8486964, 1

SMILES Fc1ccc(cc1)C1(CC1)C(=O)N1CC2CC2(C1)c1c[nH]c2ncccc12

InChI Key InChIKey=NVEWYSISVYQERO-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50390707   

Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50390707(CHEMBL2070316 | US8486964, 1)
Affinity DataIC50: 25nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Human)
Merck Serono

Curated by ChEMBL
LigandPNGBDBM50390707(CHEMBL2070316 | US8486964, 1)
Affinity DataIC50: 26nMpH: 7.4 T: 2°CAssay Description:The 11-β-HSD-1 enzyme assay was carried out in 96 well microtiter plates in a total volume of 100 μl containing 30 mM Hepes buffer, pH 7.4 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
US Patent

Target11-beta-hydroxysteroid dehydrogenase 1(Mouse)
Merck Patent

US Patent
LigandPNGBDBM50390707(CHEMBL2070316 | US8486964, 1)
Affinity DataIC50: 670nMpH: 7.4 T: 2°CAssay Description:The 11-β-HSD-1 enzyme assay was carried out in 96 well microtiter plates in a total volume of 100 μl containing 30 mM Hepes buffer, pH 7.4 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
US Patent

Target11-beta-hydroxysteroid dehydrogenase 1(Rat)
Merck Patent

US Patent
LigandPNGBDBM50390707(CHEMBL2070316 | US8486964, 1)
Affinity DataIC50: 930nMpH: 7.4 T: 2°CAssay Description:The 11-β-HSD-1 enzyme assay was carried out in 96 well microtiter plates in a total volume of 100 μl containing 30 mM Hepes buffer, pH 7.4 wi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/5/2013
Entry Details
US Patent