BDBM50392861 CHEMBL2152070
SMILES COc1ccc(F)c(c1)-c1ccc(COc2cccc(c2)[C@@H](CC(O)=O)C2CC2)cc1C1=CCCC1(C)C
InChI Key InChIKey=CHEANNSDVJOIBS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 14 hits for monomerid = 50392861
Affinity DataEC50: 3.5nMAssay Description:Agonist activity at human GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye base...More data for this Ligand-Target Pair
Affinity DataKd: 5nMAssay Description:Binding affinity to human GPR40 expressed in CHO cells by LC-MS analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 11nMAssay Description:Agonist activity at rat GPR40 transfected in HEK293 cells assessed as increase in intracellular calcium level incubated for 1 hr by Fluo-8 dye based ...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation ...More data for this Ligand-Target Pair
Affinity DataEC50: 130nMAssay Description:Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataEC50: 150nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells incubated for 60 mins by FLIPR based Ca2+ mobilization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hr...More data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serumMore data for this Ligand-Target Pair
Affinity DataEC50: 160nMAssay Description:Agonist activity at GPR40 (unknown origin) expressed in CHO cells incubated for 2 hrs measured over 20 secs in presence of human serum albumin by aeq...More data for this Ligand-Target Pair
Affinity DataEC50: 161nMAssay Description:Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as luminescence for 20 seconds interval by aequorin assay in presence of 0...More data for this Ligand-Target Pair
Affinity DataEC50: 392nMAssay Description:Positive allosteric modulation of recombinant human GPR40 expressed in HEK293 cells assessed as increase in [3H]-myo-inositol phosphate accumulation ...More data for this Ligand-Target Pair
Affinity DataEC50: 392nMAssay Description:Positive allosteric modulation of human GPR40 expressed in HEK293 cells assessed as IP1 accumulation measured after 60 mins in presence of 100% human...More data for this Ligand-Target Pair
Affinity DataEC50: 710nMAssay Description:Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 100 % human serumMore data for this Ligand-Target Pair