BDBM50430965 CHEMBL2337850

SMILES C[C@H](NC(=O)[C@@H](N)Cc1ccc(OCc2ccccc2)cc1)C(=O)N[C@@H](C[C@]1(O)C(=O)Nc2ccccc12)C(=O)NCc1ccccc1

InChI Key InChIKey=PNAOQGBEWNBVLZ-UHFFFAOYSA-N

Data  2 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50430965   

TargetProteasome subunit beta type-5(Baker's yeast)
University Paris 6

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataIC50: 9.40E+3nMAssay Description:Inhibition of chymotrypsin-like activity of yeast 20S proteasome beta-5 subunit using Suc-LLVY-AMC as substrate measured up to 45 mins by fluorescenc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
University Paris 6

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed as remaining ac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProteasome subunit beta type-9(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of human 20S immunoproteasome beta-1 using Ac-PAL-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
University Paris 6

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataKi:  2.45E+4nMAssay Description:Noncompetitive inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProteasome subunit beta type-5(Human)
University Paris 6

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataKi:  2.45E+4nMAssay Description:Noncompetitive inhibition of chymotrypsin-like activity of human constitutive 20s proteasome beta-5 subunit using Suc-LLVY-AMC as substrate assessed ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetProteasome subunit beta type-2(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataIC50: 2.48E+4nMAssay Description:Inhibition of human 20S constitutive proteasome beta-2 using BocLRR-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-10(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataIC50: 2.72E+4nMAssay Description:Inhibition of human 20S immunoproteasome beta-2 using BocLRR-AMC as substrate incubated for 15 mins measured for 45 mins by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human 20S constitutive proteasome beta-1 using Z-LLE-betaNA as substrate incubated for 15 mins measured for 45 mins by fluorescence ass...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2020
Entry Details Article
PubMed
TargetProteasome subunit beta type-1(Human)
University of Rennes 1

Curated by ChEMBL
LigandPNGBDBM50430965(CHEMBL2337850)
Affinity DataIC50: 5.12E+4nMAssay Description:Inhibition of postacid activity of human constitutive 20s proteasome beta-1 subunit using Z-LLE-betaNA as substrate assessed as remaining activity in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed