BDBM50444549 CHEMBL3099695
SMILES Fc1cc(ccc1[C@H]1CCc2cncn12)C#N
InChI Key InChIKey=USUZGMWDZDXMDG-CYBMUJFWSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 30 hits for monomerid = 50444549
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZh cells using deoxycorticosterone as substrateMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human CYP11B1 expressed in Chinese hamster V79 MZh cells using [14C]-deoxycorticosteron as substrate measured after 6 hrs by phosphoima...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of CYP11B2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human aldosterone synthase expressed in V79 MZ cellsMore data for this Ligand-Target Pair
TargetAromatase(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Affinity DataIC50: 856nMAssay Description:Inhibition of CYP19 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human CYP11B1 expressed in V79 MZ cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of CYP11B2 in human V79MZ cells using [3H]-11-deoxycorticosterone as substrate incubated for 1 hr prior to substrate addition measured aft...More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of CYP11B1 in human V79MZ cells using [3H]-11-deoxycorticosterone as substrate incubated for 1 hr prior to substrate addition measured aft...More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human CYP11B1 expressed in V79 MZh cells using [14C]-deoxycorticosterone substrate incubated for 6 hrs by HPTLC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human CYP11B2 expressed in V79 MZh cells using [14C]-deoxycorticosterone substrate incubated for 6 hrs by HPTLC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human CYP11B2 expressed in renal leiomyoblastoma cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Mouse)
Roche Pharma Research and Early Development (Pred)
Curated by ChEMBL
Roche Pharma Research and Early Development (Pred)
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of mouse CYP11B2 expressed in renal leiomyoblastoma cellsMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Rat)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 495nMAssay Description:Inhibition of rat recombinant CYP11B1 using 11-deoxycortisol as substrate by cell-based assayMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of human recombinant CYP11B1 using 11-deoxycortisol as substrate by cell-based assayMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Rat)
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Novartis Institutes For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 111nMAssay Description:Inhibition of rat recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate by cell-based assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
TargetAromatase(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human CYP19 preincubated for 10 mins followed by protein addition measured after 90 mins by fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of CYP11B2 in human NCI-H295R cells assessed as inhibition of angiotensin-2-induced aldosterone production after 24 hrs by RIAMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human CYP11B1 expressed in Chinese hamster V79 cells assessed as reduction in corticosterone production using deoxycorticosterone as su...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 cell mitochondria assessed as reduction in aldosterone production using deoxycorticoster...More data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human CYP11B2 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysisMore data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysisMore data for this Ligand-Target Pair
TargetAromatase(Human)
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Saarland University and Helmholtz Institute For Pharmaceutical Research Saarland (Hips)
Curated by ChEMBL
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of CYP19A1 (unknown origin)More data for this Ligand-Target Pair
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Human)
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Boehringer Ingelheim Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3.98E+3nMAssay Description:Inhibition of CYP17A1 (unknown origin)More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition human recombinant CYP11B1 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human recombinant CYP11B2 using 11-deoxycorticosterone as substrate after 2 hrs by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human CYP11B2 expressed in Chinese hamster V79 MZh cells using [14C]-deoxycorticosteron as substrate measured after 6 hrs by phosphoima...More data for this Ligand-Target Pair
TargetCytochrome P450 11B1, mitochondrial(Human)
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Guangzhou University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 2.90nMAssay Description:Inhibition of human CYP11B1 expressed in hamster V79MZh cells using deoxycorticosterone as substrateMore data for this Ligand-Target Pair