BDBM50507437 CHEMBL4549638

SMILES CCN(c1cc2oc(c(C(=O)NC)c2cc1-c1cccc(c1)C(=O)NC1(CC1)c1ncccn1)-c1ccc(F)cc1)S(C)(=O)=O

InChI Key InChIKey=AWFOIGBVORNGMF-UHFFFAOYSA-N

Data  4 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50507437   

TargetRNA-directed RNA polymerase(Hepatitis C virus)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50507437(CHEMBL4549638)
Affinity DataEC50:  5.40nMAssay Description:Inhibition of HCV genotype 2a JFH1 NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50507437(CHEMBL4549638)
Affinity DataEC50:  44nMAssay Description:Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase C316N mutant infected in human HuH7 replicon cells after 3 days by luciferase reporte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50507437(CHEMBL4549638)
Affinity DataEC50:  7.70nMAssay Description:Inhibition of HCV genotype 1a NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50507437(CHEMBL4549638)
Affinity DataEC50:  8.80nMAssay Description:Inhibition of HCV genotype 1b NS5B RNA dependent RNA polymerase infected in human HuH7 replicon cells after 3 days by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed