BDBM50525248 CHEMBL4450411

SMILES OC(=O)c1cc2sc(NC(=O)c3ccccc3Sc3ccc(cc3)C(F)(F)F)nc2cc1O

InChI Key InChIKey=BCOMBAJCFYTNKK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50525248   

TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50525248(CHEMBL4450411)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of GST-tagged DENV3 NS2B-NS3 serine protease expressed in Escherichia coli BL21Gold(DE3) using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50525248(CHEMBL4450411)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of DENV3 NS2B-NS3 protease using PhAc-Lys-Arg-Arg-AMC as substrate incubated for 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50525248(CHEMBL4450411)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of His-tagged DENV2 NS2B-NS3 serine protease expressed in Escherichia coli BL21 using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as substrat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetGenome polyprotein(DENV-2)
Queensland University of Technology

Curated by ChEMBL
LigandPNGBDBM50525248(CHEMBL4450411)
Affinity DataIC50: 6.60E+4nMAssay Description:Inhibition of DENV2 NS2B-NS3 protease using Boc-Gly-Arg-Arg-7-amino-4-methylcoumarin as substrate incubated for 10 mins by fluorometric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2023
Entry Details
PubMed