BDBM50530842 CHEMBL4559751

SMILES CCCOc1ccc(Cl)cc1CN(CCc1ccc(cc1)S(=O)(=O)NCC#C)C(=O)Cc1ccsc1

InChI Key InChIKey=SFPYRFRNYALLHS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50530842   

LigandPNGBDBM50530842(CHEMBL4559751)
Affinity DataIC50:  300nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs befo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50530842(CHEMBL4559751)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of NLRP3 in mouse peritoneal macrophages assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50530842(CHEMBL4559751)
Affinity DataIC50:  300nMAssay Description:Inhibition of NLRP3 inflammasome in LPS-primed mouse J774.A1 cells assessed as reduction in IL-1beta secretion preincubated for 30 mins followed by A...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50530842(CHEMBL4559751)
Affinity DataIC50:  1.59E+3nMAssay Description:Inhibition of NLRP3 in mouse peritoneal macrophages assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50530842(CHEMBL4559751)
Affinity DataIC50:  300nMAssay Description:Inhibition of NLRP3 in mouse J774A.1 cells assessed as inhibition of LPS and ATP-induced IL-1beta production pre-stimulated with LPS for 4.5 hrs befo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed