BDBM50547895 CHEMBL4751356::US11377438, Example 177

SMILES NS(=O)(=O)c1cc(NC(=O)c2cc(OC(F)(F)F)cnc2N2CCCC(F)(F)CC2)ccn1

InChI Key InChIKey=HSWWXBFOMGQCFB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50547895   

TargetSodium channel protein type 10 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50547895(CHEMBL4751356 | US11377438, Example 177)
Affinity DataIC50: 2.80nMAssay Description:The following buffers were used for the Qube recordings: External buffer for Nav1.8 Qube recording: 150 NaCl, 2 CaCl2, 5 KCl, 1 Mg Cl2, 10 HEPES, 12 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2022
Entry Details
US Patent

TargetSodium channel protein type 10 subunit alpha(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50547895(CHEMBL4751356 | US11377438, Example 177)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/22/2022
Entry Details Article
PubMed