BDBM50563426 CHEMBL4783861
SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)Nc1cc(Cl)ccc1Oc1ccc(cc1)C(=O)NCCSC#N
InChI Key InChIKey=FKIPEBVDUWFIIM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 50563426
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 0.631nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 0.631nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 4 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-CCR2-RA-(R) from human CCR2b expressed in human U2OS cell membranes pre-incubated for 0 hrs before radio ligand addition and mea...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-CCR2-RA from human CCR2b expressed in human U2OS cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 1.58nMAssay Description:Displacement of [3H]-CCR2-RA-[R] from wild type human CCR2 expressed in CHO cell membranes incubated for 2 hrs by scintillation counting methodMore data for this Ligand-Target Pair
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 5.01E+3nMAssay Description:Antagonist activity at human CCR1 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins followed by...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins followed by...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins before CCL2...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Antagonist activity at human CCR2 expressed in HEK293 cells assessed as inhibition of beta-arrestin recruitment pre-incubated for 20 mins before CCL2...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 3.98E+3nMAssay Description:Antagonist activity at human CCR5 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human CCR2 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Leiden Academic Centre For Drug Research
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Antagonist activity at human CCR2 expressed in human U2OS cell membranes as inhibition of [35S]GTPgammaS binding pre-incubated for 30 mins before CCL...More data for this Ligand-Target Pair