BDBM50571473 CHEMBL4856420::US11685734, Example 39

SMILES C[C@@H]1CN(c2cc(N3C[C@@H]4C[C@@H]4[C@@H]3Cc3ccccc3)[nH]c(=O)c2)CCO1

InChI Key InChIKey=GCKKBGHFJIZIAB-UHFFFAOYSA-N

Data  3 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50571473   

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571473BDBM50571473(CHEMBL4856420 | US11685734, Example 39)
Affinity DataKi:  4nMAssay Description:Inhibition of full length recombinant FLAG-tagged human ATM assessed as decrease in p53 S15 phosphorylation using full length myc-tagged p53 as subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetDNA-dependent protein kinase catalytic subunit(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571473BDBM50571473(CHEMBL4856420 | US11685734, Example 39)
Affinity DataKi:  7nMAssay Description:Inhibition of DNA-PK isolated from human HeLa nuclear extract using full length His-tagged p53 as substrate measured after 75 mins in presence of ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571473BDBM50571473(CHEMBL4856420 | US11685734, Example 39)
Affinity DataIC50: 26.2nMAssay Description:ATM: Recombinant, full length human FLAG-tagged ATM activity (Eurofins 14-933) was measured in an ELISA for p53 S15 phosphorylation, in a 384 well V-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/31/2023
Entry Details
US Patent

TargetSerine-protein kinase ATM(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571473BDBM50571473(CHEMBL4856420 | US11685734, Example 39)
Affinity DataIC50: 520nMAssay Description:Inhibition of ATM in human U2OS cells assessed as reduction in etoposide-stimulated KAP1 phosphorylation incubated for 60 mins by immunoreactivity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50571473BDBM50571473(CHEMBL4856420 | US11685734, Example 39)
Affinity DataKi:  750nMAssay Description:Inhibition of full length recombinant GST-tagged human VPS34 expressed in baculovirus expression system using PI/PS as substrate incubated for 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase ATR(Human)
Charles River

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50571473BDBM50571473(CHEMBL4856420 | US11685734, Example 39)
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of ATR in human HT-29 cells assessed as reduction in CHK1 phosphorylation incubated for 4 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed