BDBM50602926 CHEMBL5200160::US11814388, Compound 9
SMILES C(Oc1ccc(Nc2ncnc3[nH]ccc23)cc1)c1ccccc1
InChI Key InChIKey=GSVSRJBZRJBGOQ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 17 hits for monomerid = 50602926
Affinity DataKd: 87nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
Affinity DataKd: 87nMAssay Description:Binding affinity to wild type human EGFR partial length (R669 to V1011 residues) expressed in bacterial expression system assessed as dissociation co...More data for this Ligand-Target Pair
Affinity DataKd: 680nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
Affinity DataKd: 680nMAssay Description:Binding affinity to human partial length EGFR (R669 to V1011 residues) L858R mutant expressed in bacterial expression system assessed as dissociation...More data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:A buffer solution containing the recombinant human enzyme TTBK1 (1-1321) or TTBK2(1-450) (5-20 mU) and 50 mM Tris at pH 7.5, 0.1 mM EGTA, 0.1% p-merc...More data for this Ligand-Target Pair
Affinity DataIC50: 750nMAssay Description:Inhibition of recombinant human TTBK1 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+3nMAssay Description:A buffer solution containing the recombinant human enzyme TTBK1 (1-1321) or TTBK2(1-450) (5-20 mU) and 50 mM Tris at pH 7.5, 0.1 mM EGTA, 0.1% p-merc...More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of recombinant human TTBK2 using RICDLHDDEEDEAMSITA as substrate incubated for 30 mins in presence of 33P-gamma-ATPMore data for this Ligand-Target Pair
Affinity DataKd: 9.80E+3nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
Affinity DataKd: 9.80E+3nMAssay Description:Binding affinity to human partial length AURKB (D25 to A303 residues) expressed in mammalian system assessed as dissociation constant by DiscoverX ki...More data for this Ligand-Target Pair
Affinity DataKd: >3.00E+4nMAssay Description:Compounds 2-9 were evaluated in an ADP detection assay externally using the Kinomescan KdELECT platform from Discover X.More data for this Ligand-Target Pair
Affinity DataIC50: 4.56E+4nMAssay Description:Inhibition of EGFR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair