BDBM50622943 CHEMBL5409713

SMILES COc1ccc(Cl)cc1Cn1cc(nn1)C(=O)N1CC(F)(F)C1

InChI Key InChIKey=KXQJWLJWTNQJQJ-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50622943   

TargetNACHT, LRR and PYD domains-containing protein 3(Human)
Usona Institute

Curated by ChEMBL
LigandPNGBDBM50622943(CHEMBL5409713 | US20250243172, Compound Formula V ...)
Affinity DataKd:  0.980nMAssay Description:Binding affinity to human recombinant NLRP3 inflammasomeMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed
TargetNACHT, LRR and PYD domains-containing protein 3(Mouse)
Virginia Commonwealth University

US Patent
LigandPNGBDBM50622943(CHEMBL5409713 | US20250243172, Compound Formula V ...)
Affinity DataKd:  980nMAssay Description:Monolith NT. Automated instrument was used to measure the Kd value. A range of concentrations of NSIs were incubated and His-NLRP3 pre-labeled with R...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
11/12/2025
Entry Details
US Patent