BDBM50646993 CHEMBL5594860

SMILES COc1cccc(COc2cnc(-n3cc(C(=O)O)cn3)nc2)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50646993   

TargetNucleic acid dioxygenase ALKBH1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50646993(CHEMBL5594860)
Affinity DataIC50: 31nMAssay Description:Inhibition of N-terminal 6xHis-tagged human ALKBH1 extracted from Escherichia coli BL21(DE3) using 5'-AACTTCGTGCAGGCATGGG(6mA)TCTTGTCTACT-3'/5'-FAM-A...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNucleic acid dioxygenase ALKBH1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50646993(CHEMBL5594860)
Affinity DataKd:  156nMAssay Description:Binding affinity to 6xHis-tagged human ALKBH1 extracted from Escherichia coli BL21(DE3) assessed as dissociation constant by ITC assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetNucleic acid dioxygenase ALKBH1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50646993(CHEMBL5594860)
Affinity DataIC50: 2.62E+3nMAssay Description:Inhibition of demethylation of 6xHis-tagged human ALKBH1 extracted from Escherichia coli BL21(DE3) using 5'-AACTTCGT GCAGGCATGGGG(6mA)TCTTGTCTACT-3'/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase FTO(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50646993(CHEMBL5594860)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of demethylation of 6xHis-tagged human FTO (32 to 505 residues) extracted from Escherichia coli BL21(DE3) preincubated with compound and 5...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRNA demethylase ALKBH5(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50646993(CHEMBL5594860)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of demethylation of 6xHis-tagged human ALKBH5 (66 to 292 residues) extracted from Escherichia coli BL21(DE3) preincubated with compound an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAlpha-ketoglutarate-dependent dioxygenase alkB homolog 3(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50646993(CHEMBL5594860)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of demethylation of 6xHis-tagged human ALKBH3 (70to 286 residues) extracted from Escherichia coli BL21(DE3) by electrophoretic analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA oxidative demethylase ALKBH2(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50646993(CHEMBL5594860)
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of demethylation of 6xHis-tagged human ALKBH2 (56 to 261 residues) extracted from Escherichia coli BL21(DE3) by electrophoretic analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed