BDBM50667439 CHEMBL6188336

SMILES C[C@@H](Nc1nc2c(c3cc(=O)n(C4CC4)cc13)CC(N1CCC1)CC2)c1cccc(C(F)F)c1F

InChI Key InChIKey=WZQDGBFLABOBFF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50667439   

TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667439BDBM50667439(CHEMBL6188336)
Affinity DataIC50: 13nMAssay Description:Binding affinity to recombinant human His10-tagged SOS1 (564 to 1049 residues) assessed as inhibition of GST-tagged human KRAS G12C mutant (1 to 169 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSon of sevenless homolog 1(Human)
Schrodinger, Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667439BDBM50667439(CHEMBL6188336)
Affinity DataIC50: 58nMAssay Description:Inhibition of SOS1 in human NCI-H358 cells harboring KRAS G12C mutant assessed as reduction in ERK phosphorylation measured after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed