BDBM50667707 CHEMBL6192659::US20260132140, Example 12

SMILES CN(C)[C@@H]1CCN(c2ccc(-n3cnc(Nc4cnc(C#N)cn4)c3)cc2)C1

InChI Key InChIKey=MSQDCBLMCCHPQS-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50667707   

TargetSerine/threonine-protein kinase Chk1(Human)
BenevolentAI

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal GST-fused human full length CHK1 (1 to 476 residues) expressed in baculovirus-infected Sf21 cells using STK1 S1 as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
BenevolentAI

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 10nMAssay Description:Table 20: 2 μL enzyme/substrate solution (1 nM Chk-1 (Carna Bioscience #02-177), in solution with 30 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk1(Human)
BenevolentAI

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 450nMAssay Description:Inhibition of CHK1 in neocarzinostatin-stimulated human SW620 cells assessed as inhibition of CHK1 phosphorylation at Ser296 residue incubated for 2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
BenevolentAI

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 1.79E+3nMAssay Description:Inhibition of N-terminal GST-fused human full length CHK2 (1 to 543 residues) expressed in baculovirus-infected Sf21 cells using STK1 S1 as substrate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-2 (RSK3)(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 4.34E+3nMAssay Description:Table 24: Selected compounds of the invention were tested for their inhibitory potential of RSK1, RSK2, RSK3 and RSK4 kinases via the Eurofins Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk2(Human)
BenevolentAI

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 5.50E+3nMAssay Description:Table 23: 2 μL enzyme/substrate solution (2 nM Chk-1 (Carna Bioscience #02-162), in solution with 200 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 6.62E+3nMAssay Description:Table 24: Selected compounds of the invention were tested for their inhibitory potential of RSK1, RSK2, RSK3 and RSK4 kinases via the Eurofins Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-6(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 9.20E+3nMAssay Description:Table 24: Selected compounds of the invention were tested for their inhibitory potential of RSK1, RSK2, RSK3 and RSK4 kinases via the Eurofins Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-1(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 24: Selected compounds of the invention were tested for their inhibitory potential of RSK1, RSK2, RSK3 and RSK4 kinases via the Eurofins Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Cav1.2 transfected in CHO cells by automated electrophysiological analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
BenevolentAI

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50667707BDBM50667707(CHEMBL6192659 | US20260132140, Example 12)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Nav1.5 transfected in CHO cells by automated electrophysiological analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMed