BDBM577162 8-Cyclopropyl-10-(2,4-dimethyl-phenyl)pyrido[2',3':4,5]pyrrolo[1,2-a]pyrazin-9(8H)-one::US11472805, Example 66

SMILES Cc1ccc(-c2c3ncccc3n3ccn(C4CC4)c(=O)c23)c(C)c1

InChI Key InChIKey=FKOVNYLAGQLEDI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 577162   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577162(8-Cyclopropyl-10-(2,4-dimethyl-phenyl)pyrido[2',3'...)
Affinity DataIC50:  5.42nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577162(8-Cyclopropyl-10-(2,4-dimethyl-phenyl)pyrido[2',3'...)
Affinity DataIC50:  460nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577162(8-Cyclopropyl-10-(2,4-dimethyl-phenyl)pyrido[2',3'...)
Affinity DataIC50:  16.7nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577162(8-Cyclopropyl-10-(2,4-dimethyl-phenyl)pyrido[2',3'...)
Affinity DataIC50:  6.87nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent