BDBM577163 11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[1,2-a]pyrido[2',3':4,5]pyrrolo[1,2-d]pyrazin-10-one::US11472805, Example 67::US11472805, Example 68::US11472805, Example 69

SMILES Clc1ccc(cc1)-c1c2C(=O)N3CCC3Cn2c2cccnc12

InChI Key InChIKey=OEHQEKSCIBKRPE-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 577163   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  4.93nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  862nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  26nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  18.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  689nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  538nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A [2-825](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  8.87nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [122-736](Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  16.3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  24.3nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM577163(11-(4-Chlorophenyl)-6,6a,7,8-tetrahydro-10H-azeto[...)
Affinity DataIC50:  26nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent