BDBM578802 4-(aminomethyl)-6-(1-isopropyl-1H-pyrazol-4- yl)phthalazin-1(2H)-one::US11479551, Example 3-17::US11492351, Example 3-17

SMILES CC(C)n1cc(cn1)-c1ccc2c(c1)c(CN)n[nH]c2=O

InChI Key InChIKey=FIRHAFQRKGTUSH-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 578802   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM578802(4-(aminomethyl)-6-(1-isopropyl-1H-pyrazol-4- yl)ph...)
Affinity DataIC50:  770nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM578802(4-(aminomethyl)-6-(1-isopropyl-1H-pyrazol-4- yl)ph...)
Affinity DataIC50:  1.51E+4nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM578802(4-(aminomethyl)-6-(1-isopropyl-1H-pyrazol-4- yl)ph...)
Affinity DataIC50:  670nMAssay Description:Inhibition of MTA-bound human PRMT5 co-complexed with MEP50 using biotin labelled histone H4 peptide (1 to 15) as substrate assessed as inhibition of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM578802(4-(aminomethyl)-6-(1-isopropyl-1H-pyrazol-4- yl)ph...)
Affinity DataIC50:  1.51E+4nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProtein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

Curated by ChEMBL
LigandPNGBDBM578802(4-(aminomethyl)-6-(1-isopropyl-1H-pyrazol-4- yl)ph...)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of human PRMT5 co-complexed with MEP50 in absence of MTA using biotin labelled histone H4 peptide (1 to15) as substrate assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Homo sapiens (Human))
Mirati Therapeutics

US Patent
LigandPNGBDBM578802(4-(aminomethyl)-6-(1-isopropyl-1H-pyrazol-4- yl)ph...)
Affinity DataIC50:  770nMAssay Description:The assay uses purified human, PRMT5 enzyme to convert S-adenosyl-L-[methyl-3H]methionine plus histone H4 L-arginine to S-adenosyl-L-homocysteine plu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent