BDBM598546 N-(5-fluoro-2-(piperazin-1-yl)pyrimidin-4-yl)-1H-indazol-5-amine::US11613531, Example 214

SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CCNCC1

InChI Key InChIKey=BKOIAFICAZVOHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 598546   

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598546(US11613531, Example 214 | N-(5-fluoro-2-(piperazin...)
Affinity DataIC50: 26nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598546(US11613531, Example 214 | N-(5-fluoro-2-(piperazin...)
Affinity DataIC50: 38nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent