BDBM598557 N-(6-methyl-2-(2-methylpiperazin-1-yl)pyrimidin-4-yl)-1H-indazol-5-amine::US11613531, Example 207

SMILES CC1CNCCN1c1nc(C)cc(Nc2ccc3[nH]ncc3c2)n1

InChI Key InChIKey=KEFQUXNLAYXGGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 598557   

TargetRho-associated protein kinase 1 [1-535](Human)
Kadmon

US Patent
LigandPNGBDBM598557(US11613531, Example 207 | N-(6-methyl-2-(2-methylp...)
Affinity DataIC50: 41nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
Kadmon

US Patent
LigandPNGBDBM598557(US11613531, Example 207 | N-(6-methyl-2-(2-methylp...)
Affinity DataIC50: 104nMAssay Description:Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2023
Entry Details
US Patent