BDBM642551 US20230416221, Compound 27

SMILES CC1(C)CNC(=O)c2ccc(cc12)-c1ccnc(Nc2cccc(CS(N)(=O)=O)c2)n1

InChI Key InChIKey=SZZMGLSADKOJKF-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 642551   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
Hefei Institutes of Physical Science, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 642551BDBM642551(US20230416221, Compound 27)
Affinity DataIC50: 0.890nMAssay Description:The DMSO diluted compounds and the control compounds Dinaciclib, JSH-009, BAY-1211152, AZD4573 (all purchased from MCE, China) were mixed with the de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
US Patent

TargetCyclin-K(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 642551BDBM642551(US20230416221, Compound 27)
Affinity DataIC50: 1.20nMAssay Description:Inhibition of N-terminal GST-tagged recombinant full-length wildtype human CDK9/Cyclin K extracted from baculovirus infected Sf9 cells using RNA poly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 642551BDBM642551(US20230416221, Compound 27)
Affinity DataIC50: 10nMAssay Description:Inhibition of CDK9 in human MCF7 cells assessed as reduction in phosphorylation of RNA polymerase II at Ser2 residue incubated for 4 hrs by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9 [L156F](Human)
Hefei Institutes of Physical Science, Chinese Academy of Sciences

US Patent
LigandChemical structure of BindingDB Monomer ID 642551BDBM642551(US20230416221, Compound 27)
Affinity DataIC50: 125nMAssay Description:The DMSO diluted compounds and the control compounds Dinaciclib, JSH-009, BAY-1211152, AZD4573 (all purchased from MCE, China) were mixed with the de...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2024
Entry Details
US Patent

TargetCyclin-dependent kinase 4/6(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 642551BDBM642551(US20230416221, Compound 27)
Affinity DataIC50: 172nMAssay Description:Inhibition of CDK4/CDK6 in human MCF7 cells assessed as reduction in phosphorylation of Rb at S807/811 residue incubated for 4 hrs by immunoblotting ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 642551BDBM642551(US20230416221, Compound 27)
Affinity DataIC50: 377nMAssay Description:Inhibition of CDK7 in human MCF7 cells assessed as reduction in phosphorylation of RNA polymerase II at Ser5 residue incubated for 4 hrs by immunoblo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Hefei Institutes of Physical Science

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 642551BDBM642551(US20230416221, Compound 27)
Affinity DataIC50: 617nMAssay Description:Inhibition of CDK1 in human MCF7 cells assessed as reduction in phosphorylation of PP1alpha at T320 residue incubated for 4 hrs by immunoblotting ana...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed