BDBM707643 US12168007, Example 1::US20250049786, Example 1
SMILES CCOCN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(c3cccc(Cl)c3Cl)CC2)CC1
InChI Key InChIKey=ZMYYQDQFQSOZIA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 707643
Affinity DataKi: 0.100nMAssay Description:Table 8: CHO-K1 cells expressing human recombinant D3 receptors were washed with PBS. Cells were scraped from the plates and centrifuged at 1000×g. C...More data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Aliquoted membrane preparations were incubated with 0.7 nM [3H]spiperone (PerkinElmer) in the presence or absence of test compound in 96-well plates ...More data for this Ligand-Target Pair
Affinity DataKi: 0.871nMAssay Description:Table 4: CHO-K1 cells expressing human recombinant D2L receptors were washed with phosphate-buffered saline (PBS). Cells were scraped from the plates...More data for this Ligand-Target Pair
Affinity DataKi: 0.871nMAssay Description:Aliquoted membrane preparations were incubated with 0.16 nM [3H]spiperone (PerkinElmer) in the presence or absence of test compound in 96-well plates...More data for this Ligand-Target Pair
Affinity DataKi: 1.02nMAssay Description:Table 7: Cell cultures (CHO-K1) expressing recombinant human D3 receptors (DRD3, GenBank ID U32499, purchased from Euroscreen Fast, Brussels, BE) wer...More data for this Ligand-Target Pair
Affinity DataKi: 1.02nMAssay Description:Compounds were diluted in DMSO and binding buffer (containing 50 mM Tris, 5 mM MgCl2, 5 mM KCl, 1 mM CaCl2, 120 mM NaCl, 1 mM EDTA) and 50 μL of each...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:PathHunter CHO-K1 cells expressing tagged human D2L receptors and tagged β-arrestin-2 (Eurofins DiscoverX, Fremont, CA, USA) were seeded into 96-well...More data for this Ligand-Target Pair
Affinity DataKi: 1.95nMAssay Description:Table 3: Cultured CHO-K1 cells expressing recombinant human D2L receptors (DRD2L cAMP Hunter™, Gi cell line, Eurofins DiscoverX, Fremont, CA, USA) we...More data for this Ligand-Target Pair
Affinity DataKi: 1.95nMAssay Description:Test compounds were diluted serially in DMSO and subsequently diluted to 5% DMSO (v/w) in binding buffer (50 mM Tris, 5 mM MgCl2, 5 mM KCl, 1 mM CaCl...More data for this Ligand-Target Pair
Affinity DataEC50: 3.09nMAssay Description:PathHunter CHO-K1 cells expressing tagged human D3 receptors and tagged β-arrestin-2 (Eurofins DiscoverX, Fremont, CA, USA) were seeded into 96-well ...More data for this Ligand-Target Pair
Affinity DataEC50: 3.55nMAssay Description:Agonist activity at human D3 receptors was assayed by cAMP levels in HEK293 cells expressing recombinant human D3 receptors (BioXtal, Saint-Félix, Fr...More data for this Ligand-Target Pair
Affinity DataEC50: 3.72nMAssay Description:Agonist activity at human D2L receptors was assayed by measuring cAMP levels in CHO-K1 cells expressing human D2L receptors (Eurofins DiscoverX, Frem...More data for this Ligand-Target Pair
Affinity DataKi: 22.9nMAssay Description:Receptor membranes were prepared from the CHO-K1 recombinant AequoScreen® cell line stably expressing the human 5-HT2A receptor (PerkinElmer, Waltham...More data for this Ligand-Target Pair
Affinity DataKi: 22.9nMAssay Description:Table 11: Receptor membranes were prepared from the CHO-K1 recombinant AequoScreen® cell line stably expressing the human 5-HT2A receptor (PerkinElme...More data for this Ligand-Target Pair
Affinity DataIC50: 158nMAssay Description:CHO-K1 cells expressing human recombinant 5-HT2A receptors and Gα16 (purchased from Euroscreen Fast, Brussels, BE) in culture were cryopreserved acco...More data for this Ligand-Target Pair