BDBM744658 (2S,4S)—N-((3R,5R)-5-((2-Chloro-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamido)methyl)-1-(cyclopropanecarbonyl)pyrrolidin-3-yl)-4-fluoropyrrolidine-2-carboxamide::US20250171400, Example 6

SMILES O=C(NC[C@H]1C[C@@H](NC(=O)[C@@H]2C[C@H](F)CN2)CN1C(=O)C1CC1)c1ccc(C#Cc2ccc(CN3CCOCC3)cc2)cc1Cl

InChI Key

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 744658   

TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)TBA
LigandPNGBDBM744658((2S,4S)—N-((3R,5R)-5-((2-Chloro-4-((4-(morpholinom...)
Affinity DataIC50: 75nMAssay Description:Dilutions of test compound were pre-incubated with 5 nM P. aeruginosa or E. coli LpxC for 10 minutes at room temperature in 50 mM NaH2PO4, 500 mM suc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli (strain K12))TBA
LigandPNGBDBM744658((2S,4S)—N-((3R,5R)-5-((2-Chloro-4-((4-(morpholinom...)
Affinity DataIC50: 500nMAssay Description:Dilutions of test compound were pre-incubated with 5 nM P. aeruginosa or E. coli LpxC for 10 minutes at room temperature in 50 mM NaH2PO4, 500 mM suc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
TBA
Entry Details
US Patent