BDBM752399 US20250197405, Compound 1::US20250388583, Compound 578

SMILES Cc1ncc2c(C(N)=O)c(N)n(-c3c(C)ccc(O)c3C)c2n1

InChI Key InChIKey=KYVMPTABRNGPPL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 752399   

LigandChemical structure of BindingDB Monomer ID 752399BDBM752399(US20250197405, Compound 1 | US20250388583, Compoun...)
Affinity DataIC50: 3nMAssay Description:Compound serial dilution was performed by Echo, and the final concentrations varied from 10 μM to 0.5 nM. 5 μL/well of Enzyme solution was added to t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/14/2025
Entry Details
US Patent

TargetTyrosine-protein kinase Lck(Human)
Engine Biosciences

US Patent
LigandChemical structure of BindingDB Monomer ID 752399BDBM752399(US20250197405, Compound 1 | US20250388583, Compoun...)
Affinity DataIC50: 1.00E+3nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 752399BDBM752399(US20250197405, Compound 1 | US20250388583, Compoun...)
Affinity DataIC50: 1.00E+3nMAssay Description:Keywords: apoptosis, BH3 domain, Bcl2-A1, BIM, caspase, cancer Primary Collaborator: Todd Golub, Broad Institute, golub@broadinstitute.org Assay Over...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
5/6/2026
Entry Details
US Patent