BDBM766755 N-[3-chloro-4-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-ylmethyl)phenyl]-3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-benzamide::US12398142, Compound ZD-3-167

SMILES Cc1ccc(C(=O)NC2=CC(Cl)C(CN3CC4C=NNC4C3)C=C2)cc1C#Cc1cnc2cccnn12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 766755   

TargetTyrosine-protein kinase ABL1(Human)
Emory University

US Patent
LigandPNGBDBM766755(N-[3-chloro-4-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazo...)
Affinity DataIC50: 10.6nMAssay Description:Compounds were tested against the Abl1 target kinase and showed potencies between 0.30 and 0.64 nanomolar, compared to nilotinib which showed a poten...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/5/2025
Entry Details
US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Emory University

US Patent
LigandPNGBDBM766755(N-[3-chloro-4-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazo...)
Affinity DataIC50: 1.02E+4nMAssay Description:Compounds were tested against the Abl1 target kinase and showed potencies between 0.30 and 0.64 nanomolar, compared to nilotinib which showed a poten...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
12/5/2025
Entry Details
US Patent