BDBM807992 (R)-5-((1-(4-(3- (Methylamino)pyrrolidin- 1-yl)phenyl)-1H- imidazol-4- yl)amino) pyrazine-2-carbonitrile::US20260132140, Example 155

SMILES CN[C@@H]1CCN(c2ccc(-n3cnc(Nc4cnc(C#N)cn4)c3)cc2)C1

InChI Key InChIKey=RXMDOTJRRGAFTR-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 807992   

TargetSerine/threonine-protein kinase Chk1(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 807992BDBM807992((R)-5-((1-(4-(3- (Methylamino)pyrrolidin- 1-yl)phe...)
Affinity DataIC50: 10nMAssay Description:Table 20: 2 μL enzyme/substrate solution (1 nM Chk-1 (Carna Bioscience #02-177), in solution with 30 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-2 (RSK3)(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 807992BDBM807992((R)-5-((1-(4-(3- (Methylamino)pyrrolidin- 1-yl)phe...)
Affinity DataIC50: 822nMAssay Description:Table 24: Selected compounds of the invention were tested for their inhibitory potential of RSK1, RSK2, RSK3 and RSK4 kinases via the Eurofins Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-3(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 807992BDBM807992((R)-5-((1-(4-(3- (Methylamino)pyrrolidin- 1-yl)phe...)
Affinity DataIC50: 1.12E+3nMAssay Description:Table 24: Selected compounds of the invention were tested for their inhibitory potential of RSK1, RSK2, RSK3 and RSK4 kinases via the Eurofins Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-6(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 807992BDBM807992((R)-5-((1-(4-(3- (Methylamino)pyrrolidin- 1-yl)phe...)
Affinity DataIC50: 1.96E+3nMAssay Description:Table 24: Selected compounds of the invention were tested for their inhibitory potential of RSK1, RSK2, RSK3 and RSK4 kinases via the Eurofins Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetRibosomal protein S6 kinase alpha-1(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 807992BDBM807992((R)-5-((1-(4-(3- (Methylamino)pyrrolidin- 1-yl)phe...)
Affinity DataIC50: 3.42E+3nMAssay Description:Table 24: Selected compounds of the invention were tested for their inhibitory potential of RSK1, RSK2, RSK3 and RSK4 kinases via the Eurofins Kinase...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent

TargetSerine/threonine-protein kinase Chk2(Human)
Benevolentai Bio

US Patent
LigandChemical structure of BindingDB Monomer ID 807992BDBM807992((R)-5-((1-(4-(3- (Methylamino)pyrrolidin- 1-yl)phe...)
Affinity DataIC50: 5.50E+3nMAssay Description:Table 23: 2 μL enzyme/substrate solution (2 nM Chk-1 (Carna Bioscience #02-162), in solution with 200 μM ATP, 4 μM STK1 S1 (Cisbio #62ST1PEB) in assa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
9/23/2026
Entry Details
US Patent