BDBM808273 (S)-2-((2-((S)-2-(cyanomethyl)-5-oxopyrrolidin-1-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide::US12630561, Example 117

SMILES C[C@H](Nc1ccc2c(c1)OCCn1cc(N3C(=O)CC[C@H]3CC#N)nc1-2)C(N)=O

InChI Key InChIKey=DGYMEYFJERCLIR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 808273   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808273BDBM808273((S)-2-((2-((S)-2-(cyanomethyl)-5-oxopyrrolidin-1-y...)
Affinity DataIC50: 2.5nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808273BDBM808273((S)-2-((2-((S)-2-(cyanomethyl)-5-oxopyrrolidin-1-y...)
Affinity DataIC50: 280nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808273BDBM808273((S)-2-((2-((S)-2-(cyanomethyl)-5-oxopyrrolidin-1-y...)
Affinity DataIC50: 505nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Jiangsu Hansoh Pharmaceutical Group Co.

US Patent
LigandChemical structure of BindingDB Monomer ID 808273BDBM808273((S)-2-((2-((S)-2-(cyanomethyl)-5-oxopyrrolidin-1-y...)
Affinity DataIC50: 1.95E+3nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
12/4/2017
Entry Details
US Patent