BDBM808374 4-[5- (morpholine-4- carbonyl)-1H- pyrrol-3-yl]-N- [(3S)- piperidin-3- yl]-5- (trifluoromethyl) pyrimidin-2- amine::US20260137698, Compound CDK7-849

SMILES O=C(c1cc(-c2nc(N[C@H]3CCCNC3)ncc2C(F)(F)F)c[nH]1)N1CCOCC1

InChI Key InChIKey=UXNDHTCHIKYVTP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 808374   

Targetcdk7/cyclinh/mnat(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808374BDBM808374(4-[5- (morpholine-4- carbonyl)-1H- pyrrol-3-yl]-N-...)
Affinity DataIC50: 10nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

Targetcdk9/cyclin k(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808374BDBM808374(4-[5- (morpholine-4- carbonyl)-1H- pyrrol-3-yl]-N-...)
Affinity DataIC50: 125nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

Targetcdk2/cyclin a(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808374BDBM808374(4-[5- (morpholine-4- carbonyl)-1H- pyrrol-3-yl]-N-...)
Affinity DataIC50: 200nMAssay Description:Selected compounds disclosed herein were tested in CDK4/cyclinD1, CDK2/CycA and CDK2/cyclinE kinase assays by Nanosyn (Santa Clara, Calif.) to determ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent