BDBM808422 4-[5-(1- cyclopropyl-1H- 1,2,3,4-tetrazol-5- yl)-1H-pyrrol-3- yl]-N-(piperidin- 3-yl)-5- (trifluoromethyl)py- rimidin-2-amine::US20260137698, Compound CDK7-1103

SMILES FC(F)(F)c1cnc(N[C@H]2CCCNC2)nc1-c1c[nH]c(-c2noc(C3CC3)n2)c1

InChI Key InChIKey=LRMHBKFVMIPDFS-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 808422   

Targetcdk7/cyclinh/mnat(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808422BDBM808422(4-[5-(1- cyclopropyl-1H- 1,2,3,4-tetrazol-5- yl)-1...)
Affinity DataIC50: 10nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

Targetcdk9/cyclin k(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808422BDBM808422(4-[5-(1- cyclopropyl-1H- 1,2,3,4-tetrazol-5- yl)-1...)
Affinity DataIC50: 125nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

Targetcdk2/cyclin a(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808422BDBM808422(4-[5-(1- cyclopropyl-1H- 1,2,3,4-tetrazol-5- yl)-1...)
Affinity DataIC50: 200nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent