BDBM808430 4-{5-methyl- 3,4,6,13- tetraazatricyclo[8.3.0.02,6] trideca- 1(10),2,4,11- tetraen-11-yl}-N- [(3S)-piperidin-3- yl]-5- (trifluoromethyl)py- rimidin-2-amine::US20260137698, Compound CDK7-1236

SMILES Cc1nnc2n1CCCc1c(-c3nc(N[C@H]4CCCNC4)ncc3C(F)(F)F)c[nH]c1-2

InChI Key InChIKey=IDJUZPGEDIBKJQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 808430   

Targetcdk7/cyclinh/mnat(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808430BDBM808430(4-{5-methyl- 3,4,6,13- tetraazatricyclo[8.3.0.02,6...)
Affinity DataIC50: 10nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

Targetcdk9/cyclin k(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808430BDBM808430(4-{5-methyl- 3,4,6,13- tetraazatricyclo[8.3.0.02,6...)
Affinity DataIC50: 125nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

Targetcdk2/cyclin a(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808430BDBM808430(4-{5-methyl- 3,4,6,13- tetraazatricyclo[8.3.0.02,6...)
Affinity DataIC50: 200nMAssay Description:Compounds were added to a 384-well plate. Reaction mixtures contained 10 mM HEPES, pH 7.4, 10 mM MgCl2, 0.01% BSA, 0.0005% Tween 20, 1 mM ATP and 1 &...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent