BDBM808436 3-(2-{[(6S)-4- azaspiro[2.5]octan- 6-yl]amino}-5- (trifluoromethyl)py- rimidin-4-yl)-6- (1-methyl-1H- pyrazol-4-yl)- 1H,6H,7H- pyrrolo[2,3- c]pyridin-7-one::US20260137698, Compound CDK7-1199

SMILES Cn1cc(-n2ccc3c(-c4nc(N[C@H]5CCC6(CC6)NC5)ncc4C(F)(F)F)c[nH]c3c2=O)cn1

InChI Key InChIKey=VGTBBRZINBOCTL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 808436   

Targetcdk7/cyclinh/mnat(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808436BDBM808436(3-(2-{[(6S)-4- azaspiro[2.5]octan- 6-yl]amino}-5- ...)
Affinity DataIC50: 5nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

Targetcdk9/cyclin k(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808436BDBM808436(3-(2-{[(6S)-4- azaspiro[2.5]octan- 6-yl]amino}-5- ...)
Affinity DataIC50: 843nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

Targetcdk2/cyclin a(Human)
Joint Stock Company «Biocad»

US Patent
LigandChemical structure of BindingDB Monomer ID 808436BDBM808436(3-(2-{[(6S)-4- azaspiro[2.5]octan- 6-yl]amino}-5- ...)
Affinity DataIC50: 3.39E+3nMAssay Description:Cryopreserved human PBMCs were obtained from AllCells (cat# PB003F). After thawing/dilution protocols using RPMI medium supplemented with 5% FBS (hea...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent