BDBM808458 US20260137699, Example 21b

SMILES CC1=C(C(F)(F)F)C(C2=C(F)C3N=C(OC[C@@]45CCCN4C[C@H](F)C5)N=C4C3C(=N2)OCCN4C(C)c2cccnc2N)=C(Cl)C(N)C1

InChI Key InChIKey=DVZBWXJNTSAAHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 808458   

TargetKRas [G12V]/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 808458BDBM808458(US20260137699, Example 21b)
Affinity DataIC50: 0.0500nMAssay Description:The ASK1 enzymatic assay was run following Promega ASK1 Kinase Enzyme System (Cat #V3881). The kit provides the protocol, enzymes and all reagents ne...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent

TargetKRas/Son of Sevenless Homolog 1(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 808458BDBM808458(US20260137699, Example 21b)
Affinity DataIC50: 0.0700nMAssay Description:MYLK dissociation constants (Kd) for compounds were determined using the DiscoverX KdELECT platform. The MYLK kinase (accession number NP_444254.3) w...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
9/30/2026
Entry Details
US Patent