BDBM808582 7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-3- piperidyl]methyl]isoquinoline-3,5- diamine::US12637428, Example E10

SMILES Cc1cccc(F)c1-c1cc(NC[C@@H]2CCCNC2)c2cc(N)ncc2c1

InChI Key InChIKey=SAROZLPNNCCTPO-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 808582   

TargetSerine/threonine-protein kinase SIK2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808582BDBM808582(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-3- piperid...)
Affinity DataKi:  0.101nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808582BDBM808582(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-3- piperid...)
Affinity DataKi:  0.535nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase SIK3(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808582BDBM808582(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-3- piperid...)
Affinity DataKi:  0.966nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetTyrosine-protein kinase ABL1(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808582BDBM808582(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-3- piperid...)
Affinity DataKi:  4.83nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808582BDBM808582(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-3- piperid...)
Affinity DataKi:  32.1nMAssay Description:An enzymatic assay with recombinant human CHIT1 was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). Th...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent

TargetEphrin type-A receptor 2(Human)
Cancer Research Technology

US Patent
LigandChemical structure of BindingDB Monomer ID 808582BDBM808582(7-(2-fluoro-6-methyl-phenyl)-N5- [[(3R)-3- piperid...)
Affinity DataKi:  47.6nMAssay Description:An enzymatic assay with recombinant human AMCase was used in order to establish inhibitory activity of the compounds (Boot et al., 2001, JBC: 276). T...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
1/21/2020
Entry Details
US Patent