BDBM12342 2H-chromen-2-one::CHEMBL6466::Coumarin
SMILES O=c1ccc2ccccc2o1
InChI Key InChIKey=ZYGHJZDHTFUPRJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 73 hits for monomerid = 12342
Affinity DataKi: 48nMAssay Description:Inhibition of human carbonic anhydrase 14 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant CA12 catalytic domain by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant CA9 catalytic domain by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of human carbonic anhydrase 6 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of full length human CA1 cytosolic isoform by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of full length human recombinant CA1 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human CA1 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 after 6 hrs by stop-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 1 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.10E+3nMAssay Description:Inhibition of human full-length cytosolic CA1 after 6 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.30E+3nMAssay Description:Inhibition of human carbonic anhydrase 7 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Human)
Dalian University of Technology
Curated by ChEMBL
Dalian University of Technology
Curated by ChEMBL
Affinity DataKi: 4.06E+3nMAssay Description:Displacement of FAM-Bid peptide from recombinant N-terminal His6x-tagged human Mcl-1 expressed in Escherichia coli BL21 (DE3) incubated for 30 mins b...More data for this Ligand-Target Pair
Affinity DataKi: 5.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 5B by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 5.60E+3nMAssay Description:Inhibition of human carbonic anhydrase 3 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.80E+3nMAssay Description:Inhibition of human carbonic anhydrase 4 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 8.90E+3nMAssay Description:Inhibition of human carbonic anhydrase 12 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.10E+3nMAssay Description:Inhibition of human carbonic anhydrase 9 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of mouse carbonic anhydrase 13 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of full length human recombinant CA2 cytosolic isoform after 6 hrs by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 6 hrs by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 after 6 hrs by stop-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human full-length cytosolic CA2 after 6 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human CA2 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of full length human CA2 cytosolic isoform by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 9.20E+3nMAssay Description:Inhibition of human carbonic anhydrase 2 by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: 9.30E+3nM ΔG°: -6.86kcal/molepH: 7.0 T: 25°CAssay Description:Assays were conducted at 25 C in 20 mM sodium phosphate buffer (pH 7.0) and 0.01% bovine serum albumin unless otherwise noted. AChE concentrations we...More data for this Ligand-Target Pair
Affinity DataKi: 9.40E+3nMAssay Description:Inhibition of human carbonic anhydrase 5A by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 3.96E+4nMAssay Description:Inhibition of mouse carbonic anhydrase 15 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: 6.23E+4nMAssay Description:Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 9 catalytic domain by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant transmembrane CA12 catalytic domain after 6 hrs by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human CA9 pre-incubated for 15 mins to 24 hrs measured after 6 hrs by phenol red-based stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 12 catalytic domain by Stopped-Flow CO2 Hydrase assayMore data for this Ligand-Target Pair
Affinity DataKi: >1.00E+5nMAssay Description:Inhibition of human recombinant transmembrane CA9 catalytic domain after 6 hrs by stopped-flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 12 after 6 hrs by stop-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 13 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 14 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human carbonic anhydrase 9 after 6 hrs by stop-flow CO2 hydration assayMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 3 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 5A preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 5B preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 6 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 preincubated for 15 mins to 72 hrs measured after 6 hrs by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: >5.00E+5nMAssay Description:Inhibition of human recombinant CA12 after 6 hrs by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair