BDBM50371404 MERIOLIN 1

SMILES Nc1nccc(n1)-c1c[nH]c2ncccc12

InChI Key InChIKey=HQHSJJZIICGOIX-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50371404   

TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 26nMAssay Description:Inhibition of human recombinant CDK9/cyclin T expressed in baculovirus infected Sf9 insect cells using pRB (773 to 928 residues) as substrate after 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Human)
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 30nMAssay Description:Inhibition of CDK9/cyclin T (unknown origin) using YSPTSPSYSPTSPSYSPTSPKKK as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 90nMAssay Description:Inhibition of CDK2/cyclin A (unknown origin) using histone H1 as substrate after 30 mins in presence of [33P]-gamma-ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2019
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant CDK2/cyclin A after 30 mins by [gamma-33P]ATP based scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Csir-Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant CDK2/cyclin A expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 130nMAssay Description:Inhibition of rat recombinant GST-DYRK1A expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 510nMAssay Description:Inhibition of human recombinant CDK5/p25 expressed in baculovirus infected Sf9 insect cells after 30 mins by [gamma-33P]ATP based scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2018
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 510nMAssay Description:Inhibition of recombinant GST-CDK5/p25 expressed in Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human PDK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of human His6-tagged PDK1 using biotinylated PDKtide as substrate after 60 mins by topcount methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDK1 in human PC3 cells assessed as reduction in AKT Thr308 phosphorylation after 45 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
TargetCyclin-dependent kinase 9(Human)
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K delta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K gamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed
LigandPNGBDBM50371404(MERIOLIN 1)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2017
Entry Details Article
PubMed