BDBM50457452 SB-590885::SB590885
SMILES CN(C)CCOc1ccc(cc1)-c1nc(c([nH]1)-c1ccc2\C(CCc2c1)=N\O)-c1ccncc1
InChI Key InChIKey=MLSAQOINCGAULQ-UHFFFAOYSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50457452
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataIC50: 0.160nMAssay Description:Inhibition of full length human 6His-tagged BRAF V600E mutant expressed in baculovirus infected insect cells co-expressing human CDC37 (1 to 378 resi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataKi: 0.160nMAssay Description:Inhibition of B-Raf (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Inhibition of c-Raf (unknown origin) assessed as apparent inhibition constantMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 28nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human COLO 205 cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blo...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 58nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human HT-29 cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 58nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human SK-MEL-28 cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western bl...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 190nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human Malme-3M cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blo...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 290nMAssay Description:Inhibition of B-Raf V600E mutant expressed in human A375P cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotti...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataIC50: 290nMAssay Description:Inhibition of BRAF V600E mutant in human A375 cells assessed as reduction in ERK phosphorylation by immunoblot analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 1.10E+3nMAssay Description:Inhibition of B-Raf in human HCT-116 cells expressing K-Ras2 G13D mutant assessed as inhibition of ERK phosphorylation incubated for 60 mins by Weste...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 1.50E+3nMAssay Description:Inhibition of B-Raf in human SK-MEL-2 cells expressing N-Ras Q61R mutant assessed as inhibition of ERK phosphorylation incubated for 60 mins by Weste...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 5.10E+3nMAssay Description:Inhibition of B-Raf in human HMEC cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotting analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 6.10E+3nMAssay Description:Inhibition of B-Raf in human PrEC cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotting analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: 1.10E+4nMAssay Description:Inhibition of B-Raf in human HFF cells assessed as inhibition of ERK phosphorylation incubated for 60 mins by Western blotting analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine
Curated by ChEMBL
Albert Einstein College of Medicine
Curated by ChEMBL
Affinity DataEC50: >1.30E+4nMAssay Description:Inhibition of B-Raf in human HT-1080 cells expressing N-Ras2 Q61K mutant assessed as inhibition of ERK phosphorylation incubated for 60 mins by Weste...More data for this Ligand-Target Pair