BDBM26739 3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate::CHEMBL184238::URB 597::URB-597::URB597::US9187413, 1a (URB597)
SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
InChI Key InChIKey=ROFVXGGUISEHAM-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 131 hits for monomerid = 26739
Affinity DataIC50: 0.240nMAssay Description:Inhibition of MBP-fused human recombinant FAAH with truncated N-terminal transmembrane domain expressed in Escherichia coli T7 using D-AMC substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FAAH in Wistar rat brain intact neurons assessed as reduction in [3H]anandamide hydrolysis using [3H]anandamide as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Inhibition of rat intact neuron FAAHMore data for this Ligand-Target Pair
Affinity DataKi: 1.20nMAssay Description:Inhibition of mouse FAAH isolated from brain homogenate using [3H-ethanolamine]AEA as substrate incubated for 20 mins prior to substrate addition mea...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMpH: 7.6 T: 2°CAssay Description:In this assay, 0.05 Units of hFAAH was pre-incubated for 30 min at 37 C with 2 uL of 11a, 11b, 11f at different concentrations (0.01 - 100 uM) or veh...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain homogenates preincubated for 10 mins followed by addition of substrate measured after 30 mins by liqui...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of rat FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarinMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of FAAH in Wistar rat cerebral membrane by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of Wistar rat brain FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Inhibition of FAAH (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human FAAH assessed as hydrolysis of anandamido-amino-methyl-cumarinMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of FAAH (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.57nMAssay Description:Displacement of [3H]-anandamide from rat brain FAAH after 30 mins by scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FAAH in Wistar rat brain membranes assessed as reduction in [3H]anandamide hydrolysis using [3H]anandamide as substrate preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FAAH in rat brain membrane using anandamide[ethanolamine-3H] as substrate assessed as reduction in [3H]-ethanolamine production incubat...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of rat brain membrane FAAHMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of [3H]anandamide binding to fatty acid amide hydrolase of rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FAAH1 in Wistar rat brain homogenates using [3H]anandamide as substrate incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Displacement of [3H]anandamide from FAAH in rat brain membranes after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of FAAH in Wistar rat brain membranes using [3H]-anandamide as substrate preincubated for 10 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of mouse FAAH isolated from brain homogenate using [3H-ethanolamine]AEA as substrate incubated for 20 mins prior to substrate addition mea...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Irreversible inhibition of human recombinant FAAH assessed as hydrolysis of [3H]-AEA after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Inhibition of rat histidine tagged FAAH expressed in Escherichia coli by coumarin ester substrate fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human N-terminal FLAG-tagged/C-terminal Myc-His6 tagged FAAH2 (32 to 579 residues) expressed in COS7 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measur...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 60 mins followed by substrate addition b...More data for this Ligand-Target Pair
Affinity DataIC50: 7.70nMAssay Description:The assays for compounds described herein are amenable to high throughput screening. Preferred assays thus detect binding of the inhibitor to FAAH or...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of FAAH in mouse brain microsomes using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Inhibition of FAAH in rat brain microsomes using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 30 mins followed by substrate addition b...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant FAAH expressed in Escherichia coli assessed as hydrolysis of [3H]-AEAMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMAssay Description:Inhibition of rat brain FAAH using [3H]AEA as substrate preincubated for 10 mins at pH 8More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Inhibition of rat FAAH incubated 3 hrs prior to addition of arachidonyl-amino-methyl-coumarin amideMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human FAAH expressed in baculovirus-infected High Five cells S9 fraction using OMP substrate by fluorescence based assayMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMpH: 9.0Assay Description:Inhibition of FAAH in rat brain membrane at pH 9 using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 10 mins followed by substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of human recombinant FAAH using AMC-AA as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by ...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of human FAAH using N-(6-methoxypyridin-3-yl)octanamide as a substrate assessed as reduction in 6-methoxypyridin-3-amine formation by fluo...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of human FAAH by fluorescence-based cayman assayMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant FAAH expressed in Escherichia coli using [3H]AEA substrate incubated at 37 degC for 10 mins by liquid scintillation c...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMAssay Description:Inhibition of FAAH in rat brain membrane using N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide as substrate measured after 60 mins by reverse-phase HPLC-ba...More data for this Ligand-Target Pair
Affinity DataIC50: 48nMAssay Description:Inhibition of rat FAAH preincubated for 20 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 58nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate preincubated with protein for 0 min followed by substrate addition by ...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of FAAH in rat brain microsomes using N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide as substrate after 60 mins by fluorescence-based HPLC anal...More data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of FAAH in rat brain microsomes using N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide as substrate after 60 mins by fluorescence-based reversed ...More data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:Inhibition of FAAH in Sprague-Dawley rat brain microsomes assessed as N-(2-hydroxyethyl)-4-pyren-1-ylbutanamide conversion to 4-pyren-1-ylbutanoic ac...More data for this Ligand-Target Pair