BDBM50049949 (BK) H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH::(bradykinin triacetate)2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-3-hydroxy-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-5-guanidino-pentanoic acid::2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-3-hydroxy-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-5-guanidino-pentanoic acid::2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pentanoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonyl}-amino)-acetylamino]-3-phenyl-propionylamino}-3-hydroxy-propionyl)-pyrrolidine-2-carbonyl]-amino}-3-phenyl-propionylamino)-5-guanidino-pentanoic acid(Bradykinin)::CHEMBL406291::bradykinin

SMILES NC(N)=NCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCN=C(N)N)C(=O)O

InChI Key InChIKey=DJUMPVPKMSOPGO-UHFFFAOYSA-N

Data  6 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50049949   

TargetB2 bradykinin receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049949BDBM50049949(2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pent...)
Affinity DataEC50:  0.0490nMAssay Description:Antagonist activity at human recombinant bradykinin 2 receptor expressed in CHO cells assessed as inhibition of bradykinin-induced intracellular calc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049949BDBM50049949(2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pent...)
Affinity DataKi:  0.0650nMAssay Description:Binding affinity towards human cloned Bradykinin receptor B2 expressed in CHO cells by [3H]bradykinin displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049949BDBM50049949(2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pent...)
Affinity DataKi:  0.110nMAssay Description:Ability to bind to human cloned B2 receptor in competition binding experiments with [3H]- bradykininMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Rat)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049949BDBM50049949(2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pent...)
Affinity DataKi:  0.460nMAssay Description:Binding affinity against rat Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049949BDBM50049949(2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pent...)
Affinity DataKi:  0.650nMAssay Description:Binding affinity against human cloned Bradykinin receptor B2 expressed in CHO cells using [3H]-bradykinin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/12/2012
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049949BDBM50049949(2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pent...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]Bradykinin from human recombinant bradykinin B2 receptor expressed in CHEM1 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetB2 bradykinin receptor(Human)
National Institute of Neuroscienc

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049949BDBM50049949(2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pent...)
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]Bradykinin from human recombinant bradykinin B2 receptor expressed in CHEM1 cells after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetB1 bradykinin receptor(Human)
University of Montpellier

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50049949BDBM50049949(2-(2-{[1-(2-{2-[2-({1-[1-(2-Amino-5-guanidino-pent...)
Affinity DataKi: >10nMAssay Description:Ability to bind to human cloned B1 receptor in competition binding experiments with [3H][des-Arg10,Leu9]-Kallidin.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed