BDBM10527 (3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-methoxyphenyl)acetamido]-3-methylbutanamido]-4-oxopentanoic acid::BROMOMETHOXYPHENYL INHIBITOR::valine aspartyl ketone 29::valine aspartyl ketone 6::valine aspartyl ketone analog 10

SMILES COc1ccc(Br)cc1CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)CSCc1ccccc1

InChI Key InChIKey=VGTVMULINBNZTO-CPJSRVTESA-N

Data  13 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 10527   

TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  18nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  18nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  3.04E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  3.05E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  284nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  285nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  2.30E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  1.89E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  17.7nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  60nMpH: 7.0 T: 2°CAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  3.10E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-7(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  3.10E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCaspase-8(Homo sapiens (Human))
Merck Frosst Canada

LigandPNGBDBM10527((3S)-5-(benzylsulfanyl)-3-[(2S)-2-[1-(5-bromo-2-me...)
Affinity DataIC50:  1.89E+3nMAssay Description:The substrate peptides terminating in AMC are processed by caspases with or without inhibitors, and the accumulation of AMC was assessed with a Cytof...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed