BindingDB BDBM10620 (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate::3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl N-methyl carbamate::3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate::3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate::CHEMBL636::ENA-713::Ethyl-methyl-carbamic acid 3-((R)-1-dimethylamino-ethyl)-phenyl ester::Ethyl-methyl-carbamic acid 3-((S)-1-dimethylamino-ethyl)-phenyl ester::Ethyl-methyl-carbamic acid 3-(1-dimethylamino-ethyl)-phenyl ester::Exelon::Rivastigmine::Rivastigmine (1)::SDZ-212-713::SDZ-ENA-713

BDBM10620 (S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate::3-((1S)-1-(Dimethylamino)ethyl)phenyl N-ethyl N-methyl carbamate::3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)carbamate::3-[(1S)-1-(dimethylamino)ethyl]phenyl N-ethyl-N-methylcarbamate::CHEMBL636::ENA-713::Ethyl-methyl-carbamic acid 3-((R)-1-dimethylamino-ethyl)-phenyl ester::Ethyl-methyl-carbamic acid 3-((S)-1-dimethylamino-ethyl)-phenyl ester::Ethyl-methyl-carbamic acid 3-(1-dimethylamino-ethyl)-phenyl ester::Exelon::Rivastigmine::Rivastigmine (1)::SDZ-212-713::SDZ-ENA-713

SMILES [H][C@@](C)(N(C)C)c1cccc(OC(=O)N(C)CC)c1

InChI Key InChIKey=XSVMFMHYUFZWBK-NSHDSACASA-N

Data 1 KI 88 IC50 3 K_on

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 10620

Cholinesterase(Homo sapiens (Human))
Faculdade De Ci£Ncias Da Universidade De Lisboa

Curated by ChEMBL

BDBM10620((S)-3-(1-(dimethylamino)ethyl)phenyl ethyl(methyl)...)

IC50: 170nMAssay Description:Inhibition of BChE in human serum assessed as hydrolysis of butyrylthiocholine by Ellman's methodMore data for this Ligand-Target Pair

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Filter my 91 hits

Targets 4▿
- Acetylcholinesterase 53
- Cholinesterase 25
- Carboxylic ester hydrolase 12
- Sodium-dependent serotonin transporter 1
Publications 50▿
- Eur J Med Chem 46: 2170-84 (2011) 4
- Bioorg Med Chem 24: 1560-72 (2016) 3
- Eur J Med Chem 45: 5602-11 (2010) 2
- Eur J Med Chem 94: 195-210 (2015) 2
- Bioorg Med Chem Lett 21: 2687-91 (2011) 2
- Bioorg Med Chem 21: 146-52 (2012) 2
- Bioorg Chem 72: 301-307 (2017) 2
- J Med Chem 47: 5945-52 (2004) 2
- Bioorg Med Chem 24: 672-80 (2016) 2
- J Med Chem 51: 347-72 (2008) 2
- J Med Chem 49: 2174-85 (2006) 2
- Bioorg Chem 58: 48-52 (2015) 2
- Bioorg Med Chem Lett 15: 3834-7 (2005) 2
- Bioorg Med Chem 21: 1735-48 (2013) 2
- Bioorg Chem 71: 244-256 (2017) 2
- Bioorg Med Chem 17: 6692-8 (2009) 2
- Bioorg Chem 70: 86-93 (2017) 2
- ACS Med Chem Lett 3: 182-186 (2012) 2
- Chem Biol Drug Des 86: 1168-77 (2015) 2
- J Med Chem 51: 2027-36 (2008) 2
- Bioorg Med Chem Lett 19: 3243-6 (2009) 2
- Eur J Med Chem 46: 5435-42 (2011) 2
- J Med Chem 48: 986-94 (2005) 2
- Bioorg Med Chem Lett 16: 5840-3 (2006) 2
- J Med Chem 50: 4882-97 (2007) 2
- J Med Chem 51: 3154-70 (2008) 2
- Bioorg Med Chem 21: 7275-82 (2013) 2
- J Med Chem 45: 5260-79 (2002) 2
- Bioorg Med Chem Lett 26: 747-50 (2016) 2
- Bioorg Med Chem 22: 4717-25 (2014) 2
- Bioorg Chem 67: 84-94 (2016) 2
- J Enzyme Inhib Med Chem 26: 706-11 (2011) 2
- J Med Chem 55: 10700-15 (2012) 2
- J Med Chem 57: 8167-79 (2014) 2
- J Med Chem 51: 2883-6 (2008) 2
- Eur J Med Chem 44: 7-17 (2008) 2
- Bioorg Med Chem 22: 6124-33 (2014) 2
- J Med Chem 45: 3684-91 (2002) 2
- Bioorg Chem 60: 64-73 (2015) 1
- Eur J Med Chem 92: 799-806 (2015) 1
- J Med Chem 53: 1190-9 (2010) 1
- J Med Chem 53: 6490-505 (2010) 1
- Bioorg Med Chem Lett 24: 4749-53 (2014) 1
- Bioorg Med Chem 17: 5106-16 (2009) 1
- Bioorg Med Chem Lett 25: 4848-53 (2015) 1
- Bioorg Med Chem 20: 6313-20 (2012) 1
- Eur J Med Chem 94: 348-66 (2015) 1
- Bioorg Med Chem 23: 668-80 (2015) 1
- Chem Biol Drug Des 86: 1425-32 (2015) 1
- Bioorg Med Chem 23: 5610-8 (2015) 1
Institutions 33▿
- University Of Bologna 8
- Universit£ 8
- Zhejiang University 8
- University Of Pardubice 5
- Tehran University of Medical Sciences 5
- Sichuan University 4
- National Institutes of Health 4
- Henan University 4
- Jagiellonian University Medical College 3
- Alchemical Research 3
- National Institute On Aging 2
- Charles University 2
- University of Carthage 2
- Linyi People'S Hospital 2
- Bar-Ilan University 2
- University Of Ljubljana 2
- Hu'Nan University 2
- TBA 2
- Sention 2
- Fudan University 2
- Charles University In Prague 2
- University of Bologna 2
- Universiti Sains Malaysia 2
- Teva Pharmaceutical Industries 2
- Sun Yat-Sen University 2
- Friedrich-Schiller-UniversitäT Jena 2
- Trinity College 1
- Hunan University 1
- Tehran University Of Medical Sciences 1
- Faculdade De Ci£Ncias Da Universidade De Lisboa 1
- Csir-Central Drug Research Institute 1
- Central Drug Research Institute 1
- Panjab University 1
Affinity: 30 to 5.0E+5 nM▿
- Ki 1
- IC50 88
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1