BDBM10922 3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-yl}oxy)propyl]amino}methyl)phenyl N-heptylcarbamate hydrochloride::CHEMBL128390::aminoalkoxyheteroaryl deriv. 15

SMILES CCCCCCCNC(=O)Oc1cccc(CN(C)CCCOc2ccc3c(c2)oc2ncccc2c3=O)c1

InChI Key InChIKey=YMUNYIHDWCEAKU-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 10922   

TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM10922(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  42nMpH: 8.0 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. The absorbance changes at 412 nm were recorded for 5 min with ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM10922(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 120 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholinesterase(Homo sapiens (Human))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10922(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of human serum BuChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by Ellman's meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Homo sapiens (Human))
University of Bologna

LigandPNGBDBM10922(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  42nMAssay Description:Inhibition of acetylcholinesterase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10922(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  202nMAssay Description:Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 20 mins followed by substrate addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10922(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  400nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide preincubated for 20 mins before [14C]-anandamide addition measur...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10922(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  2.21E+3nMAssay Description:Inhibition of FAAH in rat brain membranes assessed as hydrolysis of [14C]-anandamide after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Alma Mater Studiorum-University Of Bologna

Curated by ChEMBL
LigandPNGBDBM10922(3-({methyl[3-({5-oxo-5H-chromeno[2,3-b]pyridin-8-y...)
Affinity DataIC50:  3.13E+3nMAssay Description:Inhibition of FAAH in rat brain membrane using N-arachidonoyl-[14C]-ethanolamine as substrate incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed