BDBM1107 (4R,5R,6R)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,3-bis({[3-(1H-pyrazol-3-yl)phenyl]methyl})-1,3-diazinan-2-one::(4R,5R,6R)-Tetrahydro-1,3-bis[(3-(pyrazol-3-yl)phenyl)methyl]-5-hydroxy-4-(2-phenylethyl)-6-(phenylmethyl)-2(1H)-pyrimidinone::Tetrahydropyrimidinone deriv. 68

SMILES O[C@@H]1[C@@H](CCc2ccccc2)N(Cc2cccc(c2)-c2cc[nH]n2)C(=O)N(Cc2cccc(c2)-c2cc[nH]n2)[C@@H]1Cc1ccccc1

InChI Key InChIKey=JWGRPULBGOAZNR-UJTUJTOWSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 1107   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1107((4R,5R,6R)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,...)
Affinity DataKi:  0.100nM ΔG°:  -14.2kcal/molepH: 5.5 T: 2°CAssay Description:Inhibition of HIV protease was measured by assay of the cleavage of a fluorescent peptide substrate. The fluorescent product (2-aminobenzoyl-Ala-Thr-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1107((4R,5R,6R)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,...)
Affinity DataKi:  0.100nMAssay Description:Inhibition constant of HIV protease inhibitorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1107((4R,5R,6R)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Dupont Pharmaceuticals

LigandPNGBDBM1107((4R,5R,6R)-4-benzyl-5-hydroxy-6-(2-phenylethyl)-1,...)
Affinity DataKi:  0.100nMAssay Description:Inhibitory activity of compound against HIV-1 aspartyl protease.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed