BDBM111877 US8623906, XW2-038E::US9174969, XW2-038E

SMILES COc1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccc2N(CCc2c1)C(=O)CCC(O)=O

InChI Key InChIKey=GEGMUEJWVKVTGZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 111877   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University of South Florida

US Patent
LigandPNGBDBM111877(US8623906, XW2-038E | US9174969, XW2-038E)
Affinity DataIC50:  9.00E+3nMAssay Description:IC50 values for indoline Shp2 inhibitors of the present invention, as determined by in vitro phosphotyrosine phosphatase activity (DiFMUP) assay. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
University of South Florida

US Patent
LigandPNGBDBM111877(US8623906, XW2-038E | US9174969, XW2-038E)
Affinity DataIC50:  9.00E+3nMAssay Description:In vitro Shp2 PTP activity inhibition assay for determination of IC50 was performed with a recombinant GST-Shp2 PTP domain protein using 6,8-difluoro...More data for this Ligand-Target Pair
In DepthDetails US Patent