BDBM11337 2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxypropanamide::CHEMBL316169::Hydroxamate 18

SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)C(C)C(=O)NO

InChI Key InChIKey=JRCGNOYYZQLNTH-UHFFFAOYSA-N

Data  11 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 11337   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  15nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  19nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColG(Clostridium histolyticum)
Universita Degli Studi

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  20nMAssay Description:The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  35nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  58nMAssay Description:Initial rates for the hydrolysis of the thioester substrate AcProLeuGly-S-LeuLeuGlyOEt, coupled to the reaction with 5,5-dithiobis(2-nitrobenzoic aci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  120nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Bos taurus (bovine))
Universita Degli Studi

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  136nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Universita Degli Studi

LigandPNGBDBM11337(2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxyp...)
Affinity DataKi:  195nM ΔG°:  -9.15kcal/molepH: 7.4 T: 2°CAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed