BDBM116269 US10035794, Example 46::US8637508, 46

SMILES C[C@]1(CO[C@](C)(C(N)=N1)C(F)(F)F)c1nc(NC(=O)c2nn(cc2Cl)C(F)F)ccc1F

InChI Key InChIKey=UYFPRMQOSKPOQR-JKSUJKDBSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 116269   

TargetBeta-secretase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116269(US10035794, Example 46 | US8637508, 46)
Affinity DataIC50:  10nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116269(US10035794, Example 46 | US8637508, 46)
Affinity DataIC50:  5nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116269(US10035794, Example 46 | US8637508, 46)
Affinity DataIC50:  10nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM116269(US10035794, Example 46 | US8637508, 46)
Affinity DataIC50:  5nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-2 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent