BDBM117049 US8664236, A29::US9238651, A29

SMILES COCCN(c1cc(nc(N)n1)-c1c[nH]c2ncc(cc12)-c1cnn(C)c1)c1ccccc1Cl

InChI Key InChIKey=VIHXJKNRKAYBTE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 117049   

Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM117049(US8664236, A29 | US9238651, A29)
Affinity DataIC50:  7nMAssay Description:The compound inhibits the target protein in the enzymatic PDK1 inhibition assay.More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM117049(US8664236, A29 | US9238651, A29)
Affinity DataIC50:  25.5nMpH: 8.0 T: 2°CAssay Description:The cellular assay for the determination of the PDK1 kinase activity is carried out as a Luminex assay in the 96-well format. PC3 cells are sown at...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM117049(US8664236, A29 | US9238651, A29)
Affinity DataIC50:  7nMT: 2°CAssay Description:The experimental batches are carried out in a flashplate system with 384 wells/microtitration plate.In each case, the PDK1 sample His6-PDK1(Δ1-...More data for this Ligand-Target Pair
In DepthDetails US Patent